Login

Journal Front Page

News & Events

  • April 2024 Issue delayed
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, Volume 13, Issue 2 (April 2024) Issue) schedule published on 15 April 2024 is delay due to some technical problem. It will published on 22 April 2024. Sorry for inconvenience. For other details You can vist the website http://www.ajper.com
  • Call for article for April 2024 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 March, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • January 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 1 (January 2024) Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

Formulation And Evaluation Of Ciprofloxacin Microsphere Using Different Natural Polymers

Suneel Kushwaha1*, Jagdish Rathi1, Subhendu S. Mishra2, Deepchand Mudiya2

1. NRI Institute of Pharmaceutical Sciences, Bhopal, M.P, India.

2. Sapience Bioanalytical Research Laboratory, Bhopal, M.P, India.

ABSTRACT

Microspheres of ciprofloxacin were formulated using natural polymer of Guargum and Xanthan gum by ionic crosslinking technique with an aim to prolong its release. Six formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters. Depending upon the drug to polymer ratio of Guar gum , the encapsulation efficiency , drug content and yield were found to range between 78.6±1.3 to 90.9±1.8%, 83.67±3.4 to 87.38±2.6% and 93.24±2.6 to 95.43±4.7%, respectively. Also the drug to polymer ratio of Xanthan gum , the encapsulation efficiency, drug content and yield were found to range between 64.80 ±0.025 to 68.20±0.059%, 83.83±1.76 to 88.92±1.90% and 92.38±0.045 to 93.46±0.038%, respectively. Microspheres were spherical, discrete and compact and size distribution was between 463 to 693 μm. In vitro studies were carried out at different pH for a period of 10 hr. In the formulation using Guar gum GG2 was 84.02 and Xanthan gum XG2 was 82.34 for better release.

Keywords: Ciprofloxacin, microsphere, Guargum, Xanthan gum, in vitro evaluation.antimutagenic.


[Full Text Article]